The story of Barry Seal, an American pilot who became a drug-runner for the CIA in the 1980s in a clandestine operation that would be exposed as the Iran-Contra Affair in the American Made DVD.

Knowing that he smuggles Cuban cigars into the United States as a profitable side hustle, CIA agent, Monty Schafer, recruits the daredevil TWA pilot, Barry Seal, to take aerial photographs of Sandinista bases in 1978. Before long, with Barry acting as a liaison, delivering money to General Manuel Noriega in exchange for information, Pablo Escobar's infamous Medellín Cartel enters the picture, with its co-founders, Jorge Ochoa and Carlos Lehder, wanting to have a piece of the action.

Now, Seal finds himself leading a peril-laden, cocaine-dusted triple life, and Schafer, as greedy as ever, keeps assigning increasingly dangerous tasks to his thrill-seeking go-getter, including flying guns to the Nicaraguan Contras, leading to the late 1980s Iran/Contra scandal, during the second term of the Ronald Reagan Administration.

When the CIA shuts down the scheme, Barry is left alone and arrested by the agencies. What will happen to him and his family?